I figured if the Author was breaking down, it was only a matter of time before the comic itself followed suit. And as the Author's breakdown got worse, so would the comic's degradation, starting with whatever it is that physically holds the comic together.
To make a comic like this, all you have to do is set up the panels, then fill in the extra area with a throwaway color, one you aren't going to use anywhere else in the comic. In this case, I used that ugly blinding bright blue that comes standard in Paint's color selection. Then, when you're all done, just set that color to transparent. In Photoshop, you would select the color and just delete it; in Photo Editor, you can do the same thing by using the Set Transparent Color tool on the color to be sacrificed.
Of course, that assumes you're not going to just put it over a white background, in which case, just use a white background, duh.
By the way, have I mentioned how much fun I had putting these comics together?